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    Updating the natural history of hpv and anogenital cancer

    Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología: Virus del Papiloma Humano, factores de riesgo, clínica de la infección por el VPH, implicación clínica, pesquisaje de masas, tratamiento, prevención primaria y secundaria; y problemas sociales derivados.

    La infección por el VPH es sexualmente transmitida, por lo tanto es prevenible, y puede ser curable.

    Con el objetivo de actualizar la información existente sobre el Virus del Papiloma Humano (VPH) se realizó una revisión bibliográfica de artículos basados en la evidencia de nivel I-II.

    updating the natural history of hpv and anogenital cancer-42updating the natural history of hpv and anogenital cancer-60

    This position paper published in 2014 replaces the corresponding document published in April 2009.This is a special supplement on HPV disease and prevention authored by scientists and experts in the field that updates previous reviews (20).The supplement is presented as individual peer-reviewed articles on HPV as a major public health problem, including: HPV natural history and biology, HPV therapies, current screening strategies for cervical cancer including new technologies and prospects, prophylactic HPV vaccines and their introduction, economic analyses and gaps in knowledge.The current prophylactic HPV VLP vaccines are delivered i.m.circumventing the intra-epithelial immune evasion strategies. These vaccines generate high levels of antibody and both serological and B cell memory as evidenced by persistence of antibody and robust recall responses.

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