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    Sedating agents

    Responses in sedated animals were compared to responses in animals infused with the vehicle.Fentanyl-fluanisone and thiopental had hypoalgesic actions in sedating doses.

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    Accepting the NEJM cookie is necessary to use the website.The sedative dose was defined as the highest dose that abolished the escape response without affecting the righting reflex.Female Wistar rats were chronically catheterized with a jugular vein catheter, and urine flow rate and renal clearances of inulin (glomerular filtration rate = GFR), sodium, and lithium (used as an index of proximal tubular function) were measured in the conscious, unrestrained state ( = 70 experiments), the effect of sedative doses of each drug on the nociceptive threshold was tested with the tail-flick test.Propofol and fentanyl-fluanisone reduced fractional lithium excretion by 9–13%.Only alphadolone-alphadolone, etomidate, and midazolam produced sedation without affecting renal function in rats.

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