Birth weight was positively associated with colon cancers with a HR of 1.14 (95% CI, 1.041.26) per kilogram of birth weight.For rectal cancer a significant association was not observed for birth weights below 3.5 kg.The incidence rate of colorectal cancer among cholecystectomy patients (n = 55,960) was 119 (95% CI: 106–133) per 100,000 person-years, compared to 86 (95% CI: 83–90) per 100,000 person-years among patients without a cholecystectomy (n = 574,668).Among the covariates examined, only sex and age were significant confounders and were included in the adjusted analyses.
Only cancers classified as adenocarcinomas were included in the analyses.
OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study.
Patients are stratified according to disease type (breast vs colorectal female vs colorectal male), age (49 and under vs 50-69 vs 70 and over), ECOG performance status (0-1 vs 2), baseline quality of life (UNISCALE rating less than 50% vs 50-75% vs more than 75%), and concurrent chemotherapy (yes vs no). Choosing to participate in a study is an important personal decision.
Quality of life is greatly affected; patients often find their symptoms to be socially disabling.
Although bowel dysfunction is a common event, to date there have been relatively few studies addressing bowel management.