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    Least sedating second generation antihistamine Jasmin freee chat

    Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.

    Desloratadine inhibited histamine release from human mast cells in vitro.So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.Examples of sedating antihistamines: Sedation is rare with non-sedating antihistamines, however patients should be made aware that a sedative effect may occur and performance of skilled tasks such as operating machinery or driving maybe affected.Urticaria and angioedema lasting more than 6 weeks have been designated as chronic urticaria (CU).

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